Journal article

A short term high-fat high-sucrose diet in mice impairs optic nerve recovery after injury and this is not reversed by exercise

Vicki Chrysostomou, Peter van Wijngaarden, Gregory R Steinberg, Jonathan G Crowston

EXPERIMENTAL EYE RESEARCH | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2017

Abstract

The aim of the current work was to test whether increased intake of dietary fat and sucrose in mice modifies the response of retinal ganglion cells (RGCs) of the optic nerve to injury, and whether any effects of diet are influenced by physical activity levels. C57BL/6J mice were given a high-fat high-sucrose (HFS) diet for 7 weeks, with or without exposure to regular exercise by swimming (60 min/day, 5 days/week). Injury to RGCs was subsequently induced by acute elevation of intraocular pressure (IOP) and retinas were assessed for function and structure. We report that mice on a HFS diet had similar body mass and blood glucose levels compared to mice on a control diet but suffered a 30% grea..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (Project Grant #1033506); the Dorothy Adele Edols Charitable Trust; The Miller Foundation; and the Ophthalmic Research Institute of Australia. The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government.