Journal article
The renin-angiotensin system: A possible new target for depression
J Vian, C Pereira, V Chavarria, C Köhler, B Stubbs, J Quevedo, SW Kim, AF Carvalho, M Berk, BS Fernandes
BMC Medicine | BMC | Published : 2017
Abstract
Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin-angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment and regulation of the stress response. Studies of drugs targeting the renin-angiotensin system have yielded promising results. Here, we review the potential beneficial effects of angiotensin blockers in depression and their mechanisms of action. Drugs blocking the angiotensin system have efficacy in several animal models of depression. While no randomised clinical trials were found, case reports and observational studies showed that angiotensi..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
BSF is supported by a postdoctoral fellowship from Deakin University, Australia. CAK is supported by a postdoctoral scholarship from the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES; Brazil). AFC is supported by a research fellowship award from the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq; Brazil). MB is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (grant number 1059660). The Department of Psychiatry and Behavioral Sciences of McGovern Medical School (USA) funds the Translational Psychiatry Program. The University of Texas Health Science Center at Houston (UTHealth). Laboratory of Neurosciences (Brazil) is a National Institute for Molecular Medicine centre, and a member of the Center of Excellence in Applied Neurosciences of Santa Catarina. Its research is supported by grants from CNPq (JQ), Fundacao de Amparo a Pesquisa e Inovacao do Estado de Santa Catarina (JQ); Instituto Cerebro e Mente (JQ) and Universidade do Extremo Sul Catarinense (JQ). JQ is a 1A CNPq Research Fellow. MB is supported by an NHMRC Senior Principal Research Fellowship (GNT1059660).