Journal article

Comparative effects of microvascular and macrovascular disease on the risk of major outcomes in patients with type 2 diabetes

Kamel Mohammedi, Mark Woodward, Michel Marre, Stephen Colagiuri, Mark Cooper, Stephen Harrap, Giuseppe Mancia, Neil Poulter, Bryan Williams, Sophia Zoungas, John Chalmers



BACKGROUND: Microvascular disease is associated with a high risk of macrovascular events in patients with type 2 diabetes, but the impact of macrovascular disease on the risk of microvascular events remains unknown. We sought to evaluate the respective effects of prior microvascular and macrovascular disease on the risk of major outcomes, including microvascular events, in these patients. METHODS: Participants in the Action in Diabetes and Vascular Disease: PreterAx and DiamicroN Modified-Release Controlled Evaluation (ADVANCE) trial (n = 11,140) and the ADVANCE-ON post-trial study (n = 8494) were categorized into 4 groups at baseline: dual absence of microvascular or macrovascular disease (..

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University of Melbourne Researchers


Awarded by Medical Research Council

Awarded by National Institute for Health Research

Funding Acknowledgements

KM was supported by grants from the Societe Francophone du Diabete (SFD) and the Association Diabete Risque Vasculaire (ADRV), and travel support from the Association pour le Developpement de l'Enseignement et des Recherches aupres des universites, des centres de recherches et des entreprises d'Aquitaine (ADERA).