Urinary isoprostane levels and age-related macular degeneration

C Sabanayagam; WK Lye; A Januszewski; RBBM Abdul; GCM Cheung; N Kumari; TY Wong; CY Cheng; E Lamoureux

Journal article

Urinary isoprostane levels and age-related macular degeneration

C Sabanayagam, WK Lye, A Januszewski, RBBM Abdul, GCM Cheung, N Kumari, TY Wong, CY Cheng, E Lamoureux

Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2017

DOI: 10.1167/iovs.16-21263

Abstract

PURPOSE. Oxidative stress, characterized by an excessive production of reactive oxygen intermediates has been suggested to play a role in the pathogenesis of age-related macular degeneration (AMD). We examined the association of urinary F2-isoprostanes (F2-IsoPs), a marker of lipid peroxidation and the most reliable marker of oxidative damage with AMD. METHODS. We included 238 adults with AMD and 390 age-and sex-matched controls without AMD who participated in a population-based cross-sectional study in Singapore (Singapore Chinese Eye Study, 2009-2011). AMD was graded from retinal photographs using the Wisconsin Age-Related Maculopathy Grading System. Urinary-free F2-IsoPs (pmol/mmol of cre..

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University of Melbourne Researchers

Andrzej Januszewski Author

Ecosse Lamoureux Author

Grants

Awarded by National Medical Research Council

Funding Acknowledgements

Supported by grants from the Singapore Ministry of Health's National Medical Research Council (NMRC) under its Talent Development Scheme NMRC/TA/0008/2012, NMRC/STaR/0003/2008, and Biomedical Research Council (BMRC), 08/1/35/19/550.