Journal article

Urinary Isoprostane Levels and Age-Related Macular Degeneration

Charumathi Sabanayagam, Weng Kit Lye, Andrzej Januszewski, Riswana Banu Binte Mohammed Abdul, Gemmy Chui Ming Cheung, Neelam Kumari, Tien Y Wong, Ching-Yu Cheng, Ecosse Lamoureux

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2017

Abstract

Purpose: Oxidative stress, characterized by an excessive production of reactive oxygen intermediates has been suggested to play a role in the pathogenesis of age-related macular degeneration (AMD). We examined the association of urinary F2-isoprostanes (F2-IsoPs), a marker of lipid peroxidation and the most reliable marker of oxidative damage with AMD. Methods: We included 238 adults with AMD and 390 age- and sex-matched controls without AMD who participated in a population-based cross-sectional study in Singapore (Singapore Chinese Eye Study, 2009-2011). AMD was graded from retinal photographs using the Wisconsin Age-Related Maculopathy Grading System. Urinary-free F2-IsoPs (pmol/mmol of cr..

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Grants

Awarded by Singapore Ministry of Health's National Medical Research Council (NMRC) under its Talent Development Scheme


Awarded by Biomedical Research Council (BMRC)


Funding Acknowledgements

Supported by grants from the Singapore Ministry of Health's National Medical Research Council (NMRC) under its Talent Development Scheme NMRC/TA/0008/2012, NMRC/STaR/0003/2008, and Biomedical Research Council (BMRC), 08/1/35/19/550.