Journal article
An interaction map of circulating metabolites, immune gene networks, and their genetic regulation
Artika P Nath, Scott C Ritchie, Sean G Byars, Liam G Fearnley, Aki S Havulinna, Anni Joensuu, Antti J Kangas, Pasi Soininen, Annika Wennerstrom, Lili Milani, Andres Metspalu, Satu Mannisto, Peter Wurtz, Johannes Kettunen, Emma Raitoharju, Mika Kahonen, Markus Juonala, Aarno Palotie, Mika Ala-Korpela, Samuli Ripatti Show all
GENOME BIOLOGY | BMC | Published : 2017
Abstract
BACKGROUND: Immunometabolism plays a central role in many cardiometabolic diseases. However, a robust map of immune-related gene networks in circulating human cells, their interactions with metabolites, and their genetic control is still lacking. Here, we integrate blood transcriptomic, metabolomic, and genomic profiles from two population-based cohorts (total N = 2168), including a subset of individuals with matched multi-omic data at 7-year follow-up. RESULTS: We identify topologically replicable gene networks enriched for diverse immune functions including cytotoxicity, viral response, B cell, platelet, neutrophil, and mast cell/basophil activity. These immune gene modules show complex pa..
View full abstractGrants
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by Australian Heart Foundation Career Development Fellowship
Awarded by NHMRC Early Career Fellowship
Awarded by Academy of Finland
Awarded by Competitive State Research Financing of the Expert Responsibility area of Tampere, Turku and Kuopio University Hospitals
Awarded by EU FP7
Awarded by UK Medical Research Council
Awarded by EU H2020 grants
Awarded by Estonian Research Council
Awarded by European Union through the European Regional Development Fund
Awarded by Novo Nordisk Fonden
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This study was supported by funding from National Health and Medical Research Council of Australia (NHMRC) grant APP1062227. MI was supported by an NHMRC and Australian Heart Foundation Career Development Fellowship (no. 1061435). GA was supported by an NHMRC Early Career Fellowship (no. 1090462). APN and SR were supported by an Australian Postgraduate Award. PW was supported by the Academy of Finland (no. 312476 and 312477). VS was supported by the Finnish Foundation for Cardiovascular Research. This study was further supported by the Strategic Research Funding from the University of Oulu, Finland, the Sigrid Juselius Foundation, the Academy of Finland (grant numbers 141136, 269517, 283045, 294834, and 297338), the Yrjo Jahnsson Foundation, the Emil Aaltonen Foundation, the Novo Nordisk Foundation, and the Finnish Diabetes Research Foundation. ER was supported by the Academy of Finland (no. 285902). The Young Finns Study has been financially supported by the Academy of Finland: grants 286284 (T.L.), 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Tampere, Turku and Kuopio University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjo Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; and Diabetes Research Foundation of Finnish Diabetes Association. MJ was supported by the Paulo Foundation, Maud Kuistila Foundation, and Finnish Medical Foundation. The DILGOM study and the National FINRISK study are supported by the Academy of Finland (grant numbers 139 and 635). The quantitative serum NMR metabolomics platform and its development have been supported by the Academy of Finland, TEKES-the Finnish Funding Agency for Technology and Innovation, the Sigrid Juselius Foundation, and the strategic and infrastructural research funding from the University of Oulu, Finland, as well as by the British Heart Foundation, the Wellcome Trust, and the Medical Research Council, UK. MP is also supported by EU FP7 under grant agreements 313010 (BBMRI-LPC), 305280 (MIMOmics), and HZ2020 633589 (Ageing with Elegans). MAK works in a Unit that is supported by the University of Bristol and UK Medical Research Council (MC_UU_1201/1). A.M. and L.M. were supported by EU H2020 grants 692145, the Estonian Research Council Grant IUT20-60, and European Union through the European Regional Development Fund (Project No. 2014-2020.4.01.15-0012 GENTRANSMED).