Journal article

Exploring factors related to changes in body composition, insulin sensitivity and aerobic capacity in response to a 12-week exercise intervention in overweight and obese women with and without polycystic ovary syndrome

David Scott, Cheryce L Harrison, Samantha Hutchison, Barbora de Courten, Nigel K Stepto

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2017

Abstract

OBJECTIVE: To determine factors associated with differential changes in body fat, insulin resistance and aerobic capacity following a 12-week exercise intervention in overweight and obese women with and without polycystic ovary syndrome (PCOS). METHODS: 16 overweight and obese women (9 PCOS; 7 without PCOS) completed a supervised progressive 12-week exercise program. Primary outcomes included changes in indicators of insulin sensitivity (including glucose infusion rate relative to fat-free mass [GIR/FFM]), body composition, and aerobic capacity (VO2 peak; 12 participants only). Comparisons were made between women with and without PCOS, and between participants who lost ≥5% (classified as exe..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council Project


Awarded by National Health and Medical Research Council RD Wright Biomedical Career Development Fellowship


Awarded by National Heart Foundation Fellowship


Funding Acknowledgements

This study was supported by a National Health and Medical Research Council Project Grant (APP606553) awarded to NKS. DS is supported by a National Health and Medical Research Council RD Wright Biomedical Career Development Fellowship (APP1123014). BdC is supported by a National Heart Foundation Fellowship (100864). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.