Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Mujun Sun; Rhys D Brady; David K Wright; Hyun Ah Kim; Shenpeng R Zhang; Christopher G Sobey; Maddison R Johnstone; Terence J O'Brien; Bridgette D Semple; Stuart J McDonald; Sandy R Shultz

Journal article

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Mujun Sun, Rhys D Brady, David K Wright, Hyun Ah Kim, Shenpeng R Zhang, Christopher G Sobey, Maddison R Johnstone, Terence J O'Brien, Bridgette D Semple, Stuart J McDonald, Sandy R Shultz

Brain, Behavior, and Immunity | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2017

DOI: 10.1016/j.bbi.2017.08.005

University of Melbourne Researchers

Bridgette Semple Author Medicine - Royal Melbourne Hospital

Nigel Jones Author Medicine - Royal Melbourne Hospital

Terry O'Brien Author Medicine and Radiology

Sandy Shultz Author Medicine - Royal Melbourne Hospital

Rhys Brady Author Medicine - Royal Melbourne Hospital

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by grants to SRS from the National Health and Medical Research Council (grant number 1062653) and to SJM from La Trobe University (RFA Understanding Disease), as well as fellowships to SRS and BDS from NHMRC. We acknowledge the scientific and technical assistance of the animal MRI facility at the Florey Institute of Neuroscience and Mental Health, a node of the National Imaging Facility.