Journal article

Functional genomic exploration reveals that Ss-RIOK-1 is essential for the development and survival of Strongyloides stercoralis larvae

Wang Yuan, Huan Zhou, James B Lok, Weiqiang Lei, Siyuan He, Robin B Gasser, Rui Zhou, Rui Fang, Yanqin Zhou, Junlong Zhao, Min Hu

International Journal for Parasitology | ELSEVIER SCI LTD | Published : 2017

Abstract

Protein kinase RIOK-1 is a non-ribosomal factor essential for rRNA cleavage and ribosome small subunit maturation. It is encoded in all eukaryotic organisms. The RIOK-1 encoding gene of Caenorhabditis elegans (Ce-riok-1) is expressed in the neuronal and reproductive systems in larvae and adults of this free-living nematode, and it supports larval growth and development of the adult gonad. In spite of its recognised roles in model organisms such as C. elegans, little is known about the function of this molecule in parasitic nematodes. In a previous study, we characterised the structure, transcriptional profiles and in vivo transcriptional expression patterns of the Ss-riok-1 of human and cani..

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Grants

Awarded by "Fundamental Research Funds for the Central Universities", China


Awarded by National Key Basic Research Program (973 program) of China


Awarded by National Institute of Health (NIH), USA


Awarded by Huazhong Agricultural University Scientific & Technology Self innovation Foundation


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

Special thanks to Fan Liu and Mudassar Nizaz Mughal for assistance with taking care of experimental dogs and to Dr. Bang Shen for his helpful discussions regarding the rescue experiment. This work was supported by "Fundamental Research Funds for the Central Universities", China (Program No. 2662015PY180) and "the National Key Basic Research Program (973 program) of China" (Grant No. 2015CB150300) to MH, by a grant from The National Institute of Health (NIH), USA (AI-50688) to JBL and by funds from Huazhong Agricultural University Scientific & Technology Self innovation Foundation (Program No. 2015RC005), the National Health and Medical Research Council (NHMRC) and the Australian Research Council (ARC) of Australia to RBG.