Mesenchymal Stem/Multipotent Stromal Cells from Human Decidua Basalis Reduce Endothelial Cell Activation
Manal A Alshabibi, Al Joharah Al Huqail, Tanvir Khatlani, Fawaz M Abomaray, Ahmed S Alaskar, Abdullah O Alawad, Bill Kalionis, Mohamed Hassan Abumaree
STEM CELLS AND DEVELOPMENT | MARY ANN LIEBERT, INC | Published : 2017
Recently, we reported the isolation and characterization of mesenchymal stem cells from the decidua basalis of human placenta (DBMSCs). These cells express a unique combination of molecules involved in many important cellular functions, which make them good candidates for cell-based therapies. The endothelium is a highly specialized, metabolically active interface between blood and the underlying tissues. Inflammatory factors stimulate the endothelium to undergo a change to a proinflammatory and procoagulant state (ie, endothelial cell activation). An initial response to endothelial cell activation is monocyte adhesion. Activation typically involves increased proliferation and enhanced expre..View full abstract
Awarded by King Abdulla International Medical Research Centre
The authors thank the staff and patients of the Delivery Unit, King Abdul Aziz Medical City for their help in obtaining placentae. This study was supported by grants from King Abdulla International Medical Research Centre (grant no. RC12/133).