Journal article

Mesenchymal Stem/Multipotent Stromal Cells from Human Decidua Basalis Reduce Endothelial Cell Activation

Manal A Alshabibi, Al Joharah Al Huqail, Tanvir Khatlani, Fawaz M Abomaray, Ahmed S Alaskar, Abdullah O Alawad, Bill Kalionis, Mohamed Hassan Abumaree

STEM CELLS AND DEVELOPMENT | MARY ANN LIEBERT, INC | Published : 2017

Abstract

Recently, we reported the isolation and characterization of mesenchymal stem cells from the decidua basalis of human placenta (DBMSCs). These cells express a unique combination of molecules involved in many important cellular functions, which make them good candidates for cell-based therapies. The endothelium is a highly specialized, metabolically active interface between blood and the underlying tissues. Inflammatory factors stimulate the endothelium to undergo a change to a proinflammatory and procoagulant state (ie, endothelial cell activation). An initial response to endothelial cell activation is monocyte adhesion. Activation typically involves increased proliferation and enhanced expre..

View full abstract