Catch a tiger snake by its tail: Differential toxicity, co-factor dependence and antivenom efficacy in a procoagulant clade of Australian venomous snakes
Callum Lister, Kevin Arbuckle, Timothy NW Jackson, Jordan Debono, Christina N Zdenek, Daniel Dashevsky, Nathan Dunstan, Luke Allen, Chris Hay, Brian Bush, Amber Gillett, Bryan G Fry
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | ELSEVIER SCIENCE INC | Published : 2017
A paradigm of venom research is adaptive evolution of toxins as part of a predator-prey chemical arms race. This study examined differential co-factor dependence, variations relative to dietary preference, and the impact upon relative neutralisation by antivenom of the procoagulant toxins in the venoms of a clade of Australian snakes. All genera were characterised by venoms rich in factor Xa which act upon endogenous prothrombin. Examination of toxin sequences revealed an extraordinary level of conservation, which indicates that adaptive evolution is not a feature of this toxin type. Consistent with this, the venoms did not display differences on the plasma of different taxa. Examination of ..View full abstract
Awarded by University of Queensland
BGF was funded by a University of Queensland (2016000654) Major Infrastructure and Equipment grant. JD, CZ and DD were the recipients of PhD scholarships administered by the University of Queensland.