Journal article
Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline
S Ayton, A Fazlollahi, P Bourgeat, P Raniga, A Ng, YY Lim, I Diouf, S Farquharson, J Fripp, D Ames, J Doecke, P Desmond, R Ordidge, CL Masters, CC Rowe, P Maruff, VL Villemagne, O Salvado, AI Bush
Brain | OXFORD UNIV PRESS | Published : 2017
DOI: 10.1093/brain/awx137
Abstract
The large variance in cognitive deterioration in subjects who test positive for amyloid-β by positron emission tomography indicates that convergent pathologies, such as iron accumulation, might combine with amyloid-β to accelerate Alzheimer's disease progression. Here, we applied quantitative susceptibility mapping, a relatively new magnetic resonance imaging method sensitive to tissue iron, to assess the relationship between iron, amyloid-β load, and cognitive decline in 117 subjects who underwent baseline magnetic resonance imaging and amyloid-β positron emission tomography from the Australian Imaging, Biomarkers and Lifestyle study (AIBL). Cognitive function data were collected every 18 m..
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Awarded by Alzheimer's Drug Discovery Foundation
Funding Acknowledgements
The Cooperative Research Centre for Mental Health, Commonwealth Science and Industry Research Organisation (CSIRO), National Health and Medical Research Council (NHMRC) Fellowships: GNT1103703 (A.I.B.) and GNT1100458 (S.A.), and NHMRC project grant: GNT1101533. The Florey Institute of Neuroscience and Mental Health acknowledges support from the Victorian Government, in particular funding from the Operational Infrastructure Support Grant.