Identification of very small open reading frames in the genomes of Holmes Jungle virus, Ord River virus, and Wongabel virus of the genus Hapavirus, family Rhabdoviridae
Aneta Gubala, Susan Walsh, Jane McAllister, Richard Weir, Steven Davis, Lorna Melville, Ian Mitchell, Dieter Bulach, Penny Gauci, Alex Skvortsov, David Boyle
Evolutionary Bioinformatics | SAGE PUBLICATIONS LTD | Published : 2017
Viruses of the family Rhabdoviridae infect a broad range of hosts from a variety of ecological and geographical niches, including vertebrates, arthropods, and plants. The arthropod-transmitted members of this family display considerable genetic diversity and remarkable genomic flexibility that enable coding for various accessory proteins in different locations of the genome. Here, we describe the genome of Holmes Jungle virus, isolated from Culex annulirostris mosquitoes collected in northern Australia, and make detailed comparisons with the closely related Ord River and Wongabel viruses, with a focus on identifying very small open reading frames (smORFs) in their genomes. This is the first ..View full abstract
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the funding contributed by DST Group, CSIRO, Berrimah Veterinary Laboratory and the Australian Biosecurity CRC for Emerging Infectious Disease.