Journal article
The association of the lipidomic profile with features of polycystic ovary syndrome
LJ Moran, PA Mundra, HJ Teede, PJ Meikle
Journal of Molecular Endocrinology | BIOSCIENTIFICA LTD | Published : 2017
DOI: 10.1530/JME-17-0023
Abstract
Polycystic ovary syndrome (PCOS) affects up to 18% of reproductive-aged women with reproductive and metabolic complications. While lipidomics can identify associations between lipid species and metabolic diseases, no research has examined the association of lipid species with the pathophysiological features of PCOS. The aim of this study was to examine the lipidomic profile in women with and without PCOS. This study was a cross-sectional study in 156 age-matched pre-menopausal women (18–45 years, BMI >20 kg/m2; n = 92 with PCOS, n = 64 without PCOS). Outcomes included the association between the plasma lipidomic profile (325 lipid species (24 classes) using liquid chromatography mass spectro..
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Funding Acknowledgements
L M is supported by a South Australian Cardiovascular Research Development Program Fellowship; a program collaboratively funded by the National Heart Foundation, the South Australian Department of Health and the South Australian Health and Medical Research Institute. H T is supported by a fellowship from the National Health and Medical Research Council. This work was supported by the Endocrine Society of Australia Ken Wynne Post-doctoral research award.