Multicellular Transcriptional Analysis of Mammalian Heart Regeneration
Gregory A Quaife-Ryan, Choon Boon Sim, Mark Ziemann, Antony Kaspi, Haloom Rafehi, Mirana Ramialison, Assam El-Osta, James E Hudson, Enzo R Porrello
CIRCULATION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
BACKGROUND: The inability of the adult mammalian heart to regenerate following injury represents a major barrier in cardiovascular medicine. In contrast, the neonatal mammalian heart retains a transient capacity for regeneration, which is lost shortly after birth. Defining the molecular mechanisms that govern regenerative capacity in the neonatal period remains a central goal in cardiac biology. Here, we assemble a transcriptomic framework of multiple cardiac cell populations during postnatal development and following injury, which enables comparative analyses of the regenerative (neonatal) versus nonregenerative (adult) state for the first time. METHODS: Cardiomyocytes, fibroblasts, leukocy..View full abstract
Awarded by National Health and Medical Research Council/Heart Foundation Career Development
Awarded by Australian Research Council
Drs Porrello and Hudson are supported by fellowships and project grants from the National Health and Medical Research Council, the Heart Foundation, Stem Cells Australia, the University of Queensland, and the Victorian Government's Operational Infrastructure Support Program. Dr Ramialison is supported by a National Health and Medical Research Council/Heart Foundation Career Development Fellowship (1049980) and an Australian Research Council Discovery Project grant (DP1049980). Dr El-Osta is supported by National Health and Medical Research Council project grants.