Journal article

Concise Review: New Frontiers in MicroRNA-Based Tissue Regeneration

Jessica E Frith, Enzo R Porrello, Justin J Cooper-White

STEM CELLS TRANSLATIONAL MEDICINE | WILEY | Published : 2014

Abstract

In recent years, the role of miRNAs in post-transcriptional gene regulation has come to the fore with strong evidence to indicate an important role for microRNAs (miRNAs) in the regulation of a wide range of fundamental biological processes. Notably, this includes the regulation of both endogenous tissue repair mechanisms and the growth and differentiation of stem cells (both adult and pluripotent). As a result, manipulation of miRNA signaling holds great promise for regenerative medicine, which aims to harness either endogenous or implanted cells to promote tissue repair. However, to fully realize this potential, it will be necessary to combine advances in our biological understanding with ..

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University of Melbourne Researchers

Grants

Awarded by Australian Research Council Discovery Early Career Researcher Award Fellowship


Awarded by National Heart Foundation of Australia


Funding Acknowledgements

We are grateful to Ernst Wolvetang for insightful discussions. J.E.F. is supported by an Australian Research Council Discovery Early Career Researcher Award Fellowship (DE13010098). E.R.P. is supported by grants and fellowships from the National Health and Medical Research Council and the National Heart Foundation of Australia (APP1033815 and 635530).