Concise Review: New Frontiers in MicroRNA-Based Tissue Regeneration
Jessica E Frith, Enzo R Porrello, Justin J Cooper-White
STEM CELLS TRANSLATIONAL MEDICINE | WILEY | Published : 2014
In recent years, the role of miRNAs in post-transcriptional gene regulation has come to the fore with strong evidence to indicate an important role for microRNAs (miRNAs) in the regulation of a wide range of fundamental biological processes. Notably, this includes the regulation of both endogenous tissue repair mechanisms and the growth and differentiation of stem cells (both adult and pluripotent). As a result, manipulation of miRNA signaling holds great promise for regenerative medicine, which aims to harness either endogenous or implanted cells to promote tissue repair. However, to fully realize this potential, it will be necessary to combine advances in our biological understanding with ..View full abstract
Awarded by Australian Research Council Discovery Early Career Researcher Award Fellowship
Awarded by National Heart Foundation of Australia
We are grateful to Ernst Wolvetang for insightful discussions. J.E.F. is supported by an Australian Research Council Discovery Early Career Researcher Award Fellowship (DE13010098). E.R.P. is supported by grants and fellowships from the National Health and Medical Research Council and the National Heart Foundation of Australia (APP1033815 and 635530).