Journal article
Hippo pathway effector Yap promotes cardiac regeneration
M Xin, Y Kim, LB Sutherland, M Murakami, X Qi, J McAnally, ER Porrello, AI Mahmoud, W Tan, JM Shelton, JA Richardson, HA Sadek, R Bassel-Duby, EN Olson
Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2013
Abstract
The adult mammalian heart has limited potential for regeneration. Thus, after injury, cardiomyocytes are permanently lost, and contractility is diminished. In contrast, the neonatal heart can regenerate owing to sustained cardiomyocyte proliferation. Identification of critical regulators of cardiomyocyte proliferation and quiescence represents an important step toward potential regenerative therapies. Yes-associated protein (Yap), a transcriptional cofactor in the Hippo signaling pathway, promotes proliferation of embryonic cardiomyocytes by activating the insulin-like growth factor and Wnt signaling pathways. Here we report that mice bearing mutant alleles of Yap and its paralog WW domain c..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
We thank Guo Huang, Kunhua Song, Ning Liu, Young-Jae Nam, and Arin Aurora for insightful discussions; Stefanie Dimmeler and Doris Taylor for helpful comments on the manuscript; Nadine Beetz for cardiomyocyte cDNA; Ji-Hoon Li for assistance with confocal microscopy; and Jose Cabrera for graphics. This work was supported by the National Institutes of Health (Grants HL-077439, HL-111665, HL093039, and U01-HL-100401), the American Heart Association-Jon Holden DeHaan Foundation (Grant 0970518N), Foundation Leducq Networks of Excellence, the Cancer Prevention and Research Institute of Texas, and the Robert A. Welch Foundation (Grant 1-0025, to E.N.O.). M. X. was supported by a Beginning-Grant-In-Aid from the American Heart Association.