Journal article

Risk of uterine cancer for BRCA1 and BRCA2 mutation carriers

YC Lee, RL Milne, S Lheureux, M Friedlander, SA McLachlan, KL Martin, MQ Bernardini, C Smith, S Picken, S Nesci, JL Hopper, KA Phillips

EUROPEAN JOURNAL OF CANCER | ELSEVIER SCI LTD | Published : 2017

Abstract

BACKGROUND: Whether BRCA1 and BRCA2 mutation carriers have a clinically relevant elevated risk of uterine cancer has implications for risk-reducing surgery. AIM: This multicentre, prospective cohort study assessed uterine cancer risk for mutation carriers compared with the general population. METHODS: Eligible mutation carriers were enrolled in the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) cohort study, had a uterus present and no history of uterine cancer at cohort entry. Epidemiological, lifestyle and clinical data were collected at cohort entry and updated three-yearly. Cancer events were verified using pathology reports. Follow-up was cen..

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Grants

Awarded by kConFab Follow-Up Study from Cancer Australia


Awarded by Australian National Breast Cancer Foundation


Awarded by National Health and Medical Research Council


Awarded by National Institute of Health U.S.A


Awarded by National Breast Cancer Foundation


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

This work was supported by grants to kConFab and the kConFab Follow-Up Study from Cancer Australia [grant number 809195], the Australian National Breast Cancer Foundation [grant number IF 17 kConFab], the National Health and Medical Research Council [grant numbers 454508, 288704, 145684], the National Institute of Health U.S.A. [grant number 1RO1CA159868], the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia and the Cancer Foundation of Western Australia [grant numbers not applicable]. The funding sources had no involvement in the study design; in the collection, analysis and interpretation of data; in the writing of the