Journal article

Investigating the genetic relationship between Alzheimer's disease and cancer using GWAS summary statistics

Yen-Chen Anne Feng, Kelly Cho, Sara Lindstrom, Peter Kraft, Jean Cormack, Liming Liang, Jane A Driver

HUMAN GENETICS | SPRINGER | Published : 2017

Abstract

Growing evidence from both epidemiology and basic science suggest an inverse association between Alzheimer's disease (AD) and cancer. We examined the genetic relationship between AD and various cancer types using GWAS summary statistics from the IGAP and GAME-ON consortia. Sample size ranged from 9931 to 54,162; SNPs were imputed to the 1000 Genomes European panel. Our results based on cross-trait LD Score regression showed a significant positive genetic correlation between AD and five cancers combined (colon, breast, prostate, ovarian, lung; r g = 0.17, P = 0.04), and specifically with breast cancer (ER-negative and overall; r g = 0.21 and 0.18, P = 0.035 and 0.034) and lung cancer (adenoca..

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Grants

Awarded by US Department of Veterans Affairs Merit Award Grant Clinical Science RD


Awarded by National Institutes of Health


Awarded by NATIONAL CANCER INSTITUTE


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE ON AGING


Awarded by Veterans Affairs


Funding Acknowledgements

This research was funded by the US Department of Veterans Affairs Merit Award Grant Clinical Science R&D [I01CX000934-01A1] (PI: Driver). The Genetic Association and Mechanisms in Oncology (GAME-ON) network was supported by the National Institutes of Health [U19CA148065 (DRIVE), U19CA148107 (CORECT), U19CA148127 (TRICL), and U19CA148537 (ELLIPSE)].