Investigating the genetic relationship between Alzheimer’s disease and cancer using GWAS summary statistics

YCA Feng; K Cho; S Lindstrom; P Kraft; J Cormack; K Blalock; PT Campbell; G Casey; DV Conti; CK Edlund; J Figueiredo; W James Gauderman; J Gong; RC Green; SB Gruber; JF Harju; TA Harrison; EJ Jacobs; MA Jenkins; S Jiao; L Li; Y Lin; FJ Manion; V Moreno; B Mukherjee; U Peters; L Raskin; FR Schumacher; D Seminara; G Severi; SL Stenzel; DC Thomas; JL Hopper; MC Southey; E Makalic; DF Schmidt; O Fletcher; J Peto; L Gibson; I dos Santos Silva; DJ Hunter; H Ahsan; A Whittemore; Q Waisfisz; H Meijers-Heijboer; M Adank; RB van der Luijt; AG Uitterlinden; A Hofman; A Meindl; RK Schmutzler; B Müller-Myhsok; P Lichtner; H Nevanlinna; TA Muranen; K Aittomäki; C Blomqvist; J Chang-Claude; R Hein; N Dahmen; L Beckman; L Crisponi; P Hall; K Czene; A Irwanto; J Liu; DF Easton; C Turnbull; N Rahman; Z Kote-Jarai; K Muir; G Giles; D Neal; JL Donovan; FC Hamdy; F Wiklund; H Gronberg; C Haiman; R Travis; E Riboli; S Gapstur; S Berndt; S Chanock; Y Han; L Su; Y Wei; RJ Hung; Y Brhane; J McLaughlin; P Brennan; JD McKay; H Bickeböller; A Rosenberger; RS Houlston; N Caporaso; MT Landi; J Heinrich; A Risch; X Wu; Y Ye

Journal article

Investigating the genetic relationship between Alzheimer’s disease and cancer using GWAS summary statistics

YCA Feng, K Cho, S Lindstrom, P Kraft, J Cormack, K Blalock, PT Campbell, G Casey, DV Conti, CK Edlund, J Figueiredo, W James Gauderman, J Gong, RC Green, SB Gruber, JF Harju, TA Harrison, EJ Jacobs, MA Jenkins, S Jiao Show all

Human Genetics | Published : 2017

DOI: 10.1007/s00439-017-1831-6

Abstract

Growing evidence from both epidemiology and basic science suggest an inverse association between Alzheimer’s disease (AD) and cancer. We examined the genetic relationship between AD and various cancer types using GWAS summary statistics from the IGAP and GAME-ON consortia. Sample size ranged from 9931 to 54,162; SNPs were imputed to the 1000 Genomes European panel. Our results based on cross-trait LD Score regression showed a significant positive genetic correlation between AD and five cancers combined (colon, breast, prostate, ovarian, lung; rg = 0.17, P = 0.04), and specifically with breast cancer (ER-negative and overall; rg = 0.21 and 0.18, P = 0.035 and 0.034) and lung cancer (adenocarc..

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University of Melbourne Researchers

Mark Jenkins Author

Enes Makalic Author

Grants

Awarded by Labex

Funding Acknowledgements

This research was funded by the US Department of Veterans Affairs Merit Award Grant Clinical Science R&D [I01CX000934-01A1] (PI: Driver). The Genetic Association and Mechanisms in Oncology (GAME-ON) network was supported by the National Institutes of Health [U19CA148065 (DRIVE), U19CA148107 (CORECT), U19CA148127 (TRICL), and U19CA148537 (ELLIPSE)].