Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis.
Direk Limmathurotsakul, Nick Golding, David Ab Dance, Jane P Messina, David M Pigott, Catherine L Moyes, Dionne B Rolim, Eric Bertherat, Nicholas Pj Day, Sharon J Peacock, Simon I Hay
Nat Microbiol | Published : 2016
Burkholderia pseudomallei, a highly pathogenic bacterium that causes melioidosis, is commonly found in soil in Southeast Asia and Northern Australia1,2. Melioidosis can be difficult to diagnose due to its diverse clinical manifestations and the inadequacy of conventional bacterial identification methods3. The bacterium is intrinsically resistant to a wide range of antimicrobials, and treatment with ineffective antimicrobials may result in case fatality rates (CFRs) exceeding 70%4,5. The importation of infected animals has, in the past, spread melioidosis to non-endemic areas6,7. The global distribution of B. pseudomallei and burden of melioidosis, however, remain poorly understood. Here, we ..View full abstract
Awarded by World Health Organization
Awarded by Wellcome Trust
Awarded by Medical Research Council