Particle Targeting in Complex Biological Media
Qiong Dai, Nadja Bertleff-Zieschang, Julia A Braunger, Mattias Bjornmalm, Christina Cortez-Jugo, Frank Caruso
ADVANCED HEALTHCARE MATERIALS | WILEY | Published : 2018
Over the past few decades, nanoengineered particles have gained increasing interest for applications in the biomedical realm, including diagnosis, imaging, and therapy. When functionalized with targeting ligands, these particles have the potential to interact with specific cells and tissues, and accumulate at desired target sites, reducing side effects and improve overall efficacy in applications such as vaccination and drug delivery. However, when targeted particles enter a complex biological environment, the adsorption of biomolecules and the formation of a surface coating (e.g., a protein corona) changes the properties of the carriers and can render their behavior unpredictable. For this ..View full abstract
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Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by ARC under the Australian Laureate Fellowship
This research was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036) and by the ARC under the Australian Laureate Fellowship (F.C., FL120100030). Q.D. acknowledges funding from The University of Melbourne through a Melbourne International Research Scholarship.