Conference Proceedings

Effects of Nicotine and Illicit Substance Use on Alcoholism Treatment Outcomes and Acamprosate Efficacy

Barbara J Mason, Philippe Lehert

JOURNAL OF ADDICTION MEDICINE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009

Abstract

OBJECTIVES: : To evaluate the effect of current smoking and lifetime illicit drug use on alcoholism treatment outcomes and to assess whether these factors influence acamprosate efficacy. METHODS: : This is a secondary analysis of data from the intention-to-treat population (N = 601) in a 6-month, randomized, placebo-controlled US trial of acamprosate (2 or 3 g/d). Patients met Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria for alcohol dependence and no other dependence disorders other than nicotine or cannabis, although patients with recent substance use were included. Baseline severities of current nicotine dependence and lifetime drug use were determined using ..

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