Journal article

A new approach to evaluating the effects of drug treatment in intermittent claudication

DC Charlesworth, P Lehert

Disease Management and Health Outcomes | Published : 1997

Abstract

Recently published European guidelines recommend that trials of drugs used for the management of intermittent claudication are carried out in a patient population selected according to strict inclusion and exclusion criteria, such as initial walking distance and the need to exclude patients with unstable claudication. However, it is questionable whether patients selected on this basis are representative of the general population with claudication and, therefore, whether findings of studies conducted in accordance with these guidelines can be extrapolated to the average patient who consults a physician. In a attempt to clarify these uncertainties, we have conducted a meta-analysis of 5 clinic..

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