Journal article

Quality-of-life assessment in comparative therapeutic trials and causal structure considerations in peripheral occlusive arterial disease

P Lehert

PHARMACOECONOMICS | ADIS INT LTD | Published : 2001

Abstract

When considering the use of quality of life as a primary end-point in phase III to IV comparative trials, the trial designer generally faces some unresolved questions. These include: How does one explain that some dimensions [quality-of-life (QOL) instruments usually have more than 1 dimension] are directly influenced by the studied treatments whereas others are not? How can one interpret conflicting results between conventional clinical measurements and QOL measurements, when the relationships between conventional clinical measurement and quality of life are not known? In this paper, we consider the use of Structural Equation Modelling (SEM) as a methodological alternative to answer these p..

View full abstract