Journal article

Discontinuation of metformin in type 2 diabetes patients treated with insulin

MG Wulffele, A Kooy, P Lehert, D Bets, JA Oom, BB van der Burg, AJM Donker, CDA Stehouwer

NETHERLANDS JOURNAL OF MEDICINE | VAN ZUIDEN COMMUNICATIONS | Published : 2002

Abstract

BACKGROUND: Metformin added to insulin therapy in type 2 diabetic patients improves glycaemic control and decreases the required daily dose of insulin (DDI). Metformin should be discontinued if cardiac, hepatic or renal failure develops. We examined whether glycaemic control can be maintained after metformin cessation. METHODS: We included 45 type 2 diabetic patients treated with insulin plus metformin, and 45 matched controls treated with insulin only. After discontinuation of metformin in the first group, we aimed for tight fasting and postprandial blood glucose levels, 4-7 and 4-10 mmol/l, respectively, in both groups. During 12 weeks we assessed glycaemic control every two weeks and, if ..

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