Autoantibody to aldolase in acute and chronic hepatitis

Abstract

Sera from 82 patients with acute or chronic hepatitis and 40 chronic carriers of hepatitis B were examined by ELISA and immunoblotting for reactivity with the glycolytic enzyme aldolase. The results of the ELISA tests, expressed as a percentage of a positive control, were compared to those obtained with sera from 39 patients with rubella, 11 with cytomegalovirus infection and 74 healthy subjects. The ELISA reaction with sera, expressed as mean ± standard deviation was, for 15 patients with hepatitis A, 58.3 ± 20.5%; 15 with hepatitis B, 59.5 ± 42.18; 23 with hepatitis non-A, non-B 51.1 ± 34.4%; 11 with HBsAg positive chronic active hepatitis, 70.1 < 31.5%; and 17 with autoimmune chronic acti..