A cross sectional study of markers of hepatitis B infection in Niue.

Abstract

To determine whether the island of Niue would be a suitable location to evaluate the efficacy of hepatitis B vaccine, the prevalence of hepatitis B infection in the adult population was studied. Sera were collected from 1147 of 1244 residents above the age of 20 years, and tested for the presence of hepatitis B surface antigen (HBsAg) and specific antibody to the surface and core antigens (anti-HBs and anti-HBc) by solid-phase radioimmunoassay (SPRIA). Hepatitis B was found to be hyperendemic; 11.9% of those tested were found to be carriers of HBsAg and an additional 84% had detectable levels of anti-HBs or anti-HBc indicative of current or past infection. In this population HBV infection ap..