Journal article

A carbon tetrachloride-free synthesis of N-phenyltrifluoroacetimidoyl chloride

Dylan GM Smith, Spencer J Williams

CARBOHYDRATE RESEARCH | ELSEVIER SCI LTD | Published : 2017

Abstract

N-Phenyltrifluoroacetimidoyl chloride (PTFAI-Cl) is a reagent widely used for the preparation of glycosyl N-phenyltrifluoroacetimidates. However, the most commonly applied method requires carbon tetrachloride, a hepatotoxic reagent that has been phased out under the Montreal Protocol. We report a new synthesis of N-phenyltrifluoroacetimidoyl chloride (PTFAI-Cl) using dichlorotriphenylphosphane and triethylamine.

University of Melbourne Researchers