Journal article

BROAD INTERINDIVIDUAL VARIATIONS IN CIRCULATING PROGENITOR-CELL NUMBERS INDUCED BY GRANULOCYTE-COLONY-STIMULATING FACTOR THERAPY

AW ROBERTS, E DELUCA, CG BEGLEY, R BASSER, AP GRIGG, D METCALF

STEM CELLS | ALPHAMED PRESS | Published : 1995

Abstract

The elevated white cell counts (WCC) and myeloid progenitor cell levels in the blood induced by granulocyte colony-stimulating factor (G-CSF) treatment were studied in three settings: cancer patients previously treated with chemo/radiotherapy (n = 13), untreated cancer patients (n = 5) and normal volunteers (n = 9). The inter-individual variations in progenitor cell mobilization responses to G-CSF and the impact of previous chemo/radiotherapy were investigated. The absolute levels of circulating progenitor cells, but not total white cells, were reduced significantly in the pretreated cancer patients (median 961, range 289-3355 per ml blood) as compared to untreated cancer patients (median 98..

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University of Melbourne Researchers