Journal article

Comparative efficacy and acceptability of antidepressants, psychological interventions, and their combination for depressive disorder in children and adolescents: protocol for a network meta-analysis

Xinyu Zhou, Andrea Cipriani, Yuqing Zhang, Pim Cuijpers, Sarah E Hetrick, John R Weisz, Juncai Pu, Cinzia Del Giovane, Toshiaki A Furukawa, Jurgen Barth, David Coghill, Stefan Leucht, Lining Yang, Arun V Ravindran, Peng Xie



INTRODUCTION: Depressive disorder is common in children and adolescents, with important consequences and serious impairments in terms of personal and social functioning. While both pharmacological and psychological interventions have been shown to be effective, there is still uncertainty about the balance between these and what treatment strategy should be preferred in clinical practice. Therefore, we aim to compare and rank in a network meta-analysis (NMA) the commonly used psychological, pharmacological and combined interventions for depressive disorder in children and adolescents. METHODS AND ANALYSIS: We will update the literature search of two previous NMAs for the identification of tri..

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