Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: An individual-based pooled analysis of 40 twin cohorts

K Silventoinen; A Jelenkovic; R Sund; Y Yokoyama; YM Hur; W Cozen; AE Hwang; TM Mack; C Honda; F Inui; Y Iwatani; M Watanabe; R Tomizawa; KH Pietilainen; A Rissanen; SH Siribaddana; M Hotopf; A Sumathipala; F Rijsdijk; Q Tan; D Zhang; Z Pang; M Piirtola; S Aaltonen; SY Oncel; F Aliev; E Rebato; JB Hjelmborg; K Christensen; A Skytthe; KO Kyvik; JL Silberg; LJ Eaves; TL Cutler; JR Ordonana; JF Sanchez-Romera; L Colodro-Conde; YM Song; S Yang; K Lee; CE Franz; WS Kremen; MJ Lyons; A Busjahn; TL Nelson; KE Whitfield; C Kandler; KL Jang; M Gatz; DA Butler; MA Stazi; C Fagnani; C D'Ippolito; GE Duncan; D Buchwald; NG Martin; SE Medland; GW Montgomery; HU Jeong; GE Swan; R Krasnow; PKE Magnusson; NL Pedersen; AK Dahl Aslan; TA McAdams; TC Eley; AM Gregory; P Tynelius; LA Baker; C Tuvblad; G Bayasgalan; D Narandalai; TD Spector; M Mangino; G Lachance; SA Burt; KL Klump; JR Harris; I Brandt; TS Nilsen; RF Krueger; M McGue; S Pahlen; RP Corley; BM Huibregtse; M Bartels; CEM Van Beijsterveldt; G Willemsen; JH Goldberg; F Rasmussen; AD Tarnoki; DL Tarnoki; CA Derom; RF Vlietinck; RJF Loos; JL Hopper; J Sung; HH Maes; E Turkheimer; DI Boomsma

Journal article

Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: An individual-based pooled analysis of 40 twin cohorts

K Silventoinen, A Jelenkovic, R Sund, Y Yokoyama, YM Hur, W Cozen, AE Hwang, TM Mack, C Honda, F Inui, Y Iwatani, M Watanabe, R Tomizawa, KH Pietilainen, A Rissanen, SH Siribaddana, M Hotopf, A Sumathipala, F Rijsdijk, Q Tan Show all

American Journal of Clinical Nutrition | OXFORD UNIV PRESS | Published : 2017

DOI: 10.3945/ajcn.117.153643

Abstract

Background: Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m 2 )], but factors modifying these variance components are poorly understood. Objective: We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity. Design: We used genetic structural equation modeling to analyze BMI in twins ≥20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs). Results: The heritability of BMI decreased from 0.77 (95% CI..

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