Journal article

Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407

Carla Hodson, Ji Yang, Dianna M Hocking, Kristy Azzopardi, Qianyu Chen, Jessica K Holien, Michael W Parker, Marija Tauschek, Roy M Robins-Browne



Enterotoxigenic Escherichia coli (ETEC) is the most common bacterial cause of diarrhea in children in developing countries, as well as in travelers to these countries. To cause disease, ETEC needs to produce a series of virulence proteins including enterotoxins, colonization factors and secretion pathways, which enable this pathogen to colonize the human small intestine and deliver enterotoxins to epithelial cells. Previously, a number of studies have demonstrated that CfaD, an AraC-like transcriptional regulator, plays a key role in virulence gene expression by ETEC. In this study, we carried out a transcriptomic analysis of ETEC strain, H10407, grown under different conditions, and determi..

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Funding Acknowledgements

This work was supported by grants from the Australian National Health and Medical Research Council (NHMRC). CH is a recipient of an Australian Postgraduate Award. JH is a 5point Foundation Christine Martin Fellow. MP is an NHMRC Senior Principal Research Fellow. Infrastructure support from the NHMRC Independent Research Institutes Infrastructure Support Scheme and the Victorian State Government Operational Infrastructure Support Program to St. Vincent's Institute are gratefully acknowledged.