A neutralizing anti-G-CSFR antibody blocks G-CSF-induced neutrophilia without inducing neutropenia in nonhuman primates.
Karen Scalzo-Inguanti, Katherine Monaghan, Kirsten Edwards, Eva Herzog, Danijela Mirosa, Matthew Hardy, Vicki Sorto, Huy Huynh, Steven Rakar, Daria Kurtov, Hal Braley, Nick Wilson, Samantha Busfield, Andrew Nash, Arna Andrews
Journal of Leukocyte Biology | Published : 2017
Neutrophils are the most abundant WBCs and have an essential role in the clearance of pathogens. Tight regulation of neutrophil numbers and their recruitment to sites of inflammation is critical in maintaining a balanced immune response. In various inflammatory conditions, such as rheumatoid arthritis, vasculitis, cystic fibrosis, and inflammatory bowel disease, increased serum G-CSF correlates with neutrophilia and enhanced neutrophil infiltration into inflamed tissues. We describe a fully human therapeutic anti-G-CSFR antibody (CSL324) that is safe and well tolerated when administered via i.v. infusion to cynomolgus macaques. CSL324 was effective in controlling G-CSF-mediated neutrophilia ..View full abstract