Journal article
Plasma levels of tumor necrosis factor superfamily molecules are increased in bipolar disorder
IG Barbosa, GN Vaz, NP Rocha, R Machado-Vieira, MRD Ventura, RB Huguet, ME Bauer, M Berk, AL Teixeira
Clinical Psychopharmacology and Neuroscience | KOREAN COLL NEUROPSYCHOPHARMACOLOGY | Published : 2017
Abstract
Objective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD. Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand ..
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Funding Acknowledgements
Authors would like to acknowledge the participation of volunteers in this study. We also appreciate the critical comments and expert technical assistance of members of our collaborative research groups. This work was funded by the Brazilian government agencies CAPES, CNPq and Fapemig. The funding sources had no influence on study design, data analysis, interpretation of results, writing of the manuscript, or the decision to submit the paper for publication.