Journal article

Bilirubin concentration is positively associated with haemoglobin concentration and inversely associated with albumin to creatinine ratio among Indigenous Australians: eGFR Study

JT Hughes, F Barzi, WE Hoy, GRD Jones, G Rathnayake, SW Majoni, MAB Thomas, A Sinha, A Cass, RJ MacIsaac, K O'Dea, LJ Maple-Brown

CLINICAL BIOCHEMISTRY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017

Abstract

Low serum bilirubin concentrations are reported to be strongly associated with cardio-metabolic disease, but this relationship has not been reported among Indigenous Australian people who are known to be at high risk for diabetes and chronic kidney disease (CKD). HYPOTHESIS: serum bilirubin will be negatively associated with markers of chronic disease, including CKD and anaemia among Indigenous Australians. METHOD: A cross-sectional analysis of 594 adult Aboriginal and Torres Strait Islander (TSI) people in good health or with diabetes and markers of CKD. Measures included urine albumin: creatinine ratio (ACR), estimated glomerular filtration rate (eGFR), haemoglobin (Hb) and glycated haemog..

View full abstract

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Fellowship


Awarded by NHMRC Program Grant


Funding Acknowledgements

Thanks to participants, study staff, community facilitators and investigators of the eGFR Study. Other eGFR Study Investigators are A Brown, R McDermott, K Warr, S Cherian and P Lawton. The eGFR Study was supported by the Australian National Health and Medical Research Council (NHMRC) #545205 and Sea-Swift Thursday Island. JH was supported by NHMRC Fellowship #1092576; LMB was supported by NHMRC Fellowship #1078477. FB was supported by NHMRC Program Grant #631947. The views expressed in this publication are those of the authors and do not reflect the views of the NHMRC. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.