Shift in progression rate of keratoconus before and after epithelium-off accelerated corneal collagen crosslinking

Abstract

PURPOSE: To evaluate the shift in keratoconus progression rate after corneal collagen crosslinking (CXL). SETTING: Chinese University of Hong Kong Eye Centre, Hong Kong, China. DESIGN: Prospective case series. METHOD: Accelerated epithelium-off CXL was performed in patients with progressive keratoconus. Optical coherence tomography-based corneal measurements were recorded. The data collected after the first postoperative month were used for analysis. The main outcome measure was the rate of progression of steep keratometry (K), flat K, average K, and best-fit sphere (BFS) using linear mixed-effects models. Progression was defined based on a significant slope against time in these models. RES..