Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles
Michael Liem, Ching-Seng Ang, Suresh Mathivanan
PROTEOMICS | WILEY | Published : 2017
Epidemiological studies suggest that diabetes and obesity increases the risk of colorectal cancer (CRC) and lowers the patient survival rate. An important attribute in diabetes and obesity is the presence of high levels of growth factors including insulin in blood which can activate the PI3K/Akt signalling pathway. Dysregulation of PI3K/Akt signalling pathway leads to sustained proliferative signals thereby allowing the cells susceptible to cancer. Extracellular vesicles (EVs), secreted nanovesicles of endocytic origin, are implicated in mediating the transfer of oncogenic cargo in the tumour microenvironment. In this study, CRC cells were treated with insulin to activate PI3K/Akt signaling ..View full abstract
Awarded by Australian Research Council DECRA
S.M. is supported by Australian Research Council DECRA (DE150101777). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.