Three-dimensional structure of a complex of antibody with influenza virus neuraminidase.
PM Colman, WG Laver, JN Varghese, AT Baker, PA Tulloch, GM Air, RG Webster
Nature | Published : 1987
The structure of a complex between influenza virus neuraminidase and an antibody displays features inconsistent with the inflexible 'lock and key' model of antigen-antibody binding. The structure of the antigen changes on binding, and that of the antibody may also change; the interaction therefore has some of the character of a handshake.