Journal article
Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function
RH Ritchie, CH Leo, C Qin, EJ Stephenson, MA Bowden, KD Buxton, SJ Lessard, DA Rivas, LG Koch, SL Britton, JA Hawley, OL Woodman
American Journal of Physiology Heart and Circulatory Physiology | AMER PHYSIOLOGICAL SOC | Published : 2013
Abstract
Rats selectively bred for low (LCR) or high (HCR) intrinsic running capacity simultaneously present with contrasting risk factors for cardiovascular and metabolic disease. However, the impact of these phenotypes on left ventricular (LV) morphology and microvascular function, and their progression with aging, remains unresolved. We tested the hypothesis that the LCR phenotype induces progressive age-dependent LV remodeling and impairments in microvascular function, glucose utilization, and β-adrenergic responsiveness, compared with HCR. Hearts and vessels isolated from female LCR (n = 22) or HCR (n = 26) were studied at 12 and 35 wk. Nonselected N:NIH founder rats (11 wk) were also investigat..
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Awarded by National Center for Research Resources
Funding Acknowledgements
This work was supported by National Health and Medical Research Council (NHMRC) of Australia Project Grant ID526638 (to R. H. Ritchie) and National Heart Foundation Grant-in-Aid G-09M-4348 (to J. A. Hawley and O. L. Woodman) and supported in part by the Victorian Government's Operational Infrastructure Support Program. R. H. Ritchie is an NHMRC Senior Research Fellow (ID472673). The LCR-HCR rat model system was funded by the National Center for Research Resources Grant R24 RR017718 and is currently supported by the Office of Research Infrastructure Programs/OD Grant ROD012098A from the National Institutes of Health.