Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages.
Katharine M Irvine, Melanie R Andrews, Manuel A Fernandez-Rojo, Kate Schroder, Christopher J Burns, Stephen Su, Andrew F Wilks, Robert G Parton, David A Hume, Matthew J Sweet
J Leukoc Biol | Published : 2009
M-CSF/CSF-1 supports the proliferation and differentiation of monocytes and macrophages. In mice, CSF-1 also promotes proinflammatory responses in vivo by regulating mature macrophage functions, but little is known about the acute effects of this growth factor on mature human macrophages. Here, we show that in contrast to its effects on mouse bone marrow-derived macrophages, CSF-1 did not induce expression of urokinase plasminogen activator mRNA, repress expression of apolipoprotein E mRNA, or prime LPS-induced TNF and IL-6 secretion in human monocyte-derived macrophages (HMDM) from several independent donors. Instead, we show by expression profiling that CSF-1 modulates the HMDM transcripto..View full abstract
Awarded by Medical Research Council