Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

CJ Burns; MF Harte; X Bu; E Fantino; M Giarrusso; M Joffe; M Kurek; FS Legge; P Razzino; S Su; H Treutlein; SS Wan; J Zeng; AF Wilks

Journal article

Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

CJ Burns, MF Harte, X Bu, E Fantino, M Giarrusso, M Joffe, M Kurek, FS Legge, P Razzino, S Su, H Treutlein, SS Wan, J Zeng, AF Wilks

Bioorganic and Medicinal Chemistry Letters | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2009

DOI: 10.1016/j.bmcl.2008.12.073

Abstract

A series of 2-(α-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported. © 2009 Elsevier Ltd. All rights reserved.

Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

Abstract

University of Melbourne Researchers

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