Discovery of 2-(alpha-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS.
Christopher J Burns, Michael F Harte, Xianyong Bu, Emmanuelle Fantino, Marilena Giarrusso, Max Joffe, Margarita Kurek, Fiona S Legge, Pasquale Razzino, Stephen Su, Herbert Treutlein, Soo San Wan, Jun Zeng, Andrew F Wilks
Bioorg Med Chem Lett | Published : 2009
A series of 2-(alpha-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported.