Absence of platinum salt sensitivity in autocatalyst workers exposed to tetraamine platinum dichloride

Abstract

Background Platinum salt sensitivity (PSS) is well recognized following occupational exposure to platinum salts, though specific platinum compounds have been suggested to be non-allergenic. We report on a cohort of autocatalyst workers exposed to tetraamine platinum dichloride (TPC) and other platinumgroup elements. Methods All subjects employed at an autocatalyst production plant undertook medical surveillance with symptoms, examination findings and results of skin prick testing and spirometry prospectively recorded. Environmental testing of the workplace was also performed to determine the level of exposure. Results Twenty-six subjects had a mean duration of employment of 46 (630) months a..