Journal article

Identification of a genetic locus modulating splenomegaly induced by granulocyte colony-stimulating factor in mice

AW Roberts, M Hasegawa, D Metcalf, SJ Foote

LEUKEMIA | STOCKTON PRESS | Published : 2000


Clinically detectable splenomegaly and splenic rupture are uncommon but potentially life-threatening consequences of G-CSF administration. Increased spleen size in mice injected with G-CSF is a complex genetic trait amenable to investigation in experimental inter-strain crosses by quantitative trait analysis. A quantitative trait locus (QTL) with highly significant linkage (LOD 7.9) for splenomegaly was identified within a 22 centimorgan (cM) region on chromosome 1. Inheritance of a C57BL/6 haplotype in this region was associated with a greater spleen weight. The relevance of this locus was confirmed by analysing the responses of mice congenic for the distal 12 cM of this region (C57BL/6 and..

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University of Melbourne Researchers