Journal article

Genetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor

AW Roberts, S Foote, WS Alexander, C Scott, L Robb, D Metcalf

BLOOD | W B SAUNDERS CO | Published : 1997

Abstract

The mechanisms involved in the mobilization of progenitor cells into the blood by granulocyte colony-stimulating factor (G-CSF) and other cytokines are poorly understood. To identify important influences on this complex process, in vivo murine models were used. Granulocyte-macrophage colony-stimulating factor (GM-CSF) transgenic, Max41 transgenic, W/Wv, Mpl-null, GM-CSF receptor (beta chain)-null mice, wild-type littermate controls, and six inbred strains of mice were injected with 200 microg/kg/d G-CSF for 5 days. Three parameters of response were monitored: white blood cell count (WCC), peripheral blood progenitor cell (PBPC) numbers, and spleen weight. In all genotypes studied, G-CSF indu..

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