Journal article

Mix11 and Oct4 proteins are transiently co-expressed in differentiating mouse and human embryonic stem cells

AK Mossman, K Sourris, E Ng, EG Stanley, AG Elefanty

STEM CELLS AND DEVELOPMENT | MARY ANN LIEBERT, INC | Published : 2005

Abstract

Embryonic stem cells (ESCs) have the capacity to form all the tissues in the body and hence, directed differentiation of ESCs along specific lineages represents a means to generate therapeutically useful cell types. It has been postulated that, during in vitro differentiation, ES cells sequentially pass through similar developmental stages as cells in the embryo. The availability of reagents that identify these stages would facilitate the monitoring and optimization of ESC differentiation. One key stage, the development of endodermal and mesodermal precursors in the early embryo, is marked by the transient expression of the transcription factor, Mixl1 and the stem cell gene, Oct4. In order t..

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