Journal article

Limitations of apparent diffusion coefficient-based models in characterizing non-gaussian diffusion.

Chunlei Liu, Roland Bammer, Michael E Moseley

Magn Reson Med | Published : 2005

Abstract

Diffusion in complex heterogeneous structures, for example, the neural fiber system, is non-gaussian. Recently, several methods have been introduced to address the issue of non-gaussian diffusion in multifiber systems. Some are based on apparent diffusion coefficient (ADC) analysis; and some are based on q-space analysis. Here, using a simple mathematic derivation, ADC-based models are shown to be mathematically self-inconsistent in the presence of non-gaussian diffusion. Monte Carlo simulation on restricted diffusion is applied to demonstrate the poor data fitting that can result from ADC-based models. Specific comparisons are performed between two generalized diffusion tensor imaging metho..

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Awarded by NIBIB NIH HHS


Awarded by NINDS NIH HHS


Awarded by NCRR NIH HHS