Automated method for generating the arterial input function on perfusion-weighted MR imaging: validation in patients with stroke.
Michael Mlynash, Irina Eyngorn, Roland Bammer, Michael Moseley, David C Tong
American Journal of Neuroradiology | Published : 2005
BACKGROUND AND PURPOSE: The choice of arterial input function (AIF) can have a profound effect on the blood flow maps generated on perfusion-weighted MR imaging (PWI). Automation of this process could substantially reduce operator dependency, increase consistency, and accelerate PWI analysis. We created an automated AIF identification program (auto-AIF) and validated its performance against conventional manual methods. METHODS: We compared the auto-AIF against manually derived AIFs from multisection PWIs of 22 patients with stroke. Time to peak, curve width, curve height, and voxel location determined with both techniques were compared. The time to maximum of the tissue residue function (Tma..View full abstract