Diffusion MR imaging in multiple sclerosis: technical aspects and challenges.
E Pagani, R Bammer, MA Horsfield, M Rovaris, A Gass, O Ciccarelli, M Filippi
AJNR Am J Neuroradiol | Published : 2007
SUMMARY: Diffusion tensor (DT) MR imaging has frequently been applied in multiple sclerosis (MS) because of its ability to detect and quantify disease-related changes of the tissue microstructure within and outside T2-visible lesions. DT MR imaging data collection places high demands on scanner hardware and, though the acquisition and postprocessing can be relatively straightforward, numerous challenges remain in improving the reproducibility of this technique. Although there are some issues concerning image quality, echo-planar imaging is the most widely used acquisition scheme for diffusion imaging studies. Once the DT is estimated, indexes conveying the size, shape, and orientation of the..View full abstract