Journal article

Timely antiretroviral prophylaxis during pregnancy effectively reduces HIV mother-to-child transmission in eight counties in China: a prospective study during 2004-2011

Qian Wang, Linhong Wang, Liwen Fang, Ailing Wang, Xi Jin, Fang Wang, Xiaoyan Wang, Yaping Qiao, Sheena G Sullivan, Shannon Rutherford, Lei Zhang

SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2016

Abstract

This study investigates the improvement of the prevention of mother-to-child transmission (PMTCT) of Human Immunodeficiency Virus (HIV) in China during 2004-2011. A clinic-based prospective study was conducted among HIV-positive pregnant women and their children in eight counties across China. Associated factors of mother-to-child transmission were analyzed using regression analysis. A total of 1,387 HIV+ pregnant women and 1,377 HIV-exposed infants were enrolled. The proportion of pregnant women who received HIV testing increased significantly from 45.1% to 98.9% during 2004-2011. Among whom, the proportion that received antiretroviral (ARV) prophylaxis increased from 61% to 96%, and the co..

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University of Melbourne Researchers

Grants

Awarded by National Key Technology Research and Development Program of China during the 10th Five-Year Plan


Awarded by National Center for women and children's health, China CDC


Funding Acknowledgements

The authors would like to thank Yuan Cheng, Yang Yuyan, Re Ziyan, Liu Lifen, Yan Yu, Cui Guosheng and Zhi Yuhong for their efforts for patient recruitment and blood samples collection. They also thank Zhang Yan, Sha Wuli, Sun Dingyong and Qiu Xiaoxia for their contributions to this project. This work was supported by the National Key Technology Research and Development Program of China during the 10th Five-Year Plan (2004BA719A03) and project grant from National Center for women and children's health, China CDC (2013FY005).