Journal article
Loci associated with ischaemic stroke and its subtypes (SiGN): A genome-wide association study
J Rosand, BD Mitchell, H Ay, PIW de Bakker, K Gwinn, SJ Kittner, A Lindgren, JF Meschia, SL Pulit, CLM Sudlow, V Thijs, D Woo, BB Worrall, DK Arnett, O Benavente, JW Cole, M Dichgans, RP Grewal, C Jern, JJ Conde Show all
Lancet Neurology | ELSEVIER SCIENCE INC | Published : 2016
Abstract
Background: The discovery of disease-associated loci through genome-wide association studies (GWAS) is the leading genetic approach to the identification of novel biological pathways underlying diseases in humans. Until recently, GWAS in ischaemic stroke have been limited by small sample sizes and have yielded few loci associated with ischaemic stroke. We did a large-scale GWAS to identify additional susceptibility genes for stroke and its subtypes. Methods: To identify genetic loci associated with ischaemic stroke, we did a two-stage GWAS. In the first stage, we included 16 851 cases with state-of-the-art phenotyping data and 32 473 stroke-free controls. Cases were aged 16 to 104 years, rec..
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Awarded by National Institutes of Health
Funding Acknowledgements
US National Institute of Neurological Disorders and Stroke, National Institutes of Health.